NHD Extra November 17: Issue 129




2 Hyman M (2016). Eat fat, get thin: Why the fat we eat is the key to sustained weight loss and vibrant health. Little, Brown

3 Mosley M (2016). The 8-week Blood Sugar Diet: How to Beat Diabetes Fast (and Stay off Medication). Simon and Schuster

4 Deakin T (2015). Eat Fat: Step-by-Step Guide to Low Carb Living. X-PERT Health

5 Public Health England (2015). NHS Diabetes Prevention Programme (NHS DPP) Non-diabetic hyperglycaemia. Produced by: National Cardiovascular Intelligence Network (NCVIN)


7 Type 2 diabetes in adults: management, NICE guideline [NG28]. Published date: December 2015. Last updated: May 2017


9 Bang HO, Dyerberg J and Hjørne N (1976). The composition of food consumed by Greenland Eskimos. Journal of Internal Medicine, 200 (1‐6), 69-73

10 Bjerregaard P, Young TK and Hegele RA (2003). Low incidence of cardiovascular disease among the Inuit - what is the evidence? Atherosclerosis, 166(2), 351-357.

11 www.xperthealth.org.uk/Portals/0/Downloads/High%20fat,%20low%20carb%20diets%20and%20the%20evidence_Diabetes%20UK%202015_reduced%20memory.pdf

12 Unwin D and Unwin J (2014). Low carbohydrate diet to achieve weight loss and improve HbA1c in Type 2 diabetes and pre‐diabetes: experience from one general practice. Practical Diabetes, 31(2), 76-79

13 Dyson PA, Beatty S and Matthews DR (2007). A low‐carbohydrate diet is more effective in reducing body weight than healthy eating in both diabetic and non‐diabetic subjects. Diabetic Medicine, 24(12), 1430-1435

14 Feinman RD, Pogozelski WK, Astrup A, Bernstein RK, Fine EJ, Westman EC and Nielsen JV (2015). Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base. Nutrition, 31(1), 1-13

15 Ajala O, English P and Pinkney J (2013). Systematic review and meta-analysis of different dietary approaches to the management of Type 2 diabetes. The American Journal of Clin Nutr, 97(3), 505-516

16 Boden G et al. Effect of a low carbohydrate diet on appetite, blood glucose levels and insulin resistance in obese patients with Type 2 diabetes. Annals of internal medicine 142.6 (2005): 403-411

17 Noakes M et al. Comparison of isocaloric very low carbohydrate/high saturated fat and high carbohydrate/low saturated fat diets on body composition and cardiovascular risk. Nutrition & Metabolism 3.1 (2006): 7

18 Volek JS et al. Carbohydrate restriction has a more favorable impact on the metabolic syndrome than a low fat diet. Lipids 44.4 (2009): 297-309

19 www.diabetes.org.uk/professionals/position-statements-reports/food-nutrition-lifestyle/low-carb-diets-for-people-with-diabetes

More information:

• www.diabetes.org.uk/about_us/news/carbohydrates-and-diabetes-debate

• http://healthinsightuk.org/2014/11/13/high-fat-low-carb-diet-for-diabetes-a-gps-tale/


1 SACN (2015). Carbohydrates and Health

2 Accurso et al (2008). Dietary carbohydrate restriction in Type 2 diabetes mellitus and metabolic syndrome: time for a critical appraisal

3 Pogozelski et al (2005). The metabolic effects of low carbohydrate diets and incorporation into a biochemistry course (http://onlinelibrary.wiley.com/doi/10.1002/bmb.2005.494033022445/full)

4 GOSH website: Ketogenic Diet (accessed July 2017: www.gosh.nhs.uk/health-professionals/clinical-guidelines/ketogenic-diet)

5 Cross (2010). Dietary therapies - an old idea with a new lease of life

6 NICE (2017). NICE Pathways - Epilepsy Overview

7 Neal et al (2009). A randomised trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy

8 Epilepsy Foundation. Modified Atkins Diet (accessed July 2017: www.epilepsy.com/learn/treating-seizures-and-epilepsy/dietary-therapies/modified-atkins-diet)

9 Epilepsy Foundation. The LGIT and the Ketogenic Diet (accessed July 2017: www.epilepsy.com/article/2007/5/low-glycemic-index-treatment-and-ketogenic-diet

10 Matthew’s Friends. MAD & LGIT (accessed July 2017: www.matthewsfriends.org/keto-therapies/keto-introduction/modified-ketogenic-diets-mad-lgit/)

11 Mansoor et al (2016). Effects of low carbohydrate diets vs low-fat diets on body weight and cardiovascular risk factors: a meta-analysis of RCTs

12 Hession et al (2008). Systematic review of RCTs of low carbohydrate vs low fat/low calorie diets in the management of obesity and its comorbidities

13 Denke (2001). Metabolic effects of high protein, low carbohydrate diets

14 Freedman et al (2001). Popular diets: A scientific review

15 Johnstone (1996). Effect of overfeeding macronutrients on day-to-day food intake in man

16 Dyson et al (2010). An assessment of low carbohydrate or low fat diets for weight loss at two-year's follow-up

17 Blomquist and Grilo (2011). Predictive Significance of Changes in Dietary Restraint in Obese Patients with Binge Eating Disorder During Treatment

18 Castaneda-Gonzalez et al (2011). Effects of low carbohydrate diets on weight and glycaemic control among Type 2 diabetes individuals: a systemic review of RCT greater than 12 weeks

19 Naude et al (2014). Low carbohydrate versus isoenergetic balanced diets for reducing weight and cardiovascular risk: a systematic review and meta-analysis


20 Marcias and Shapre (2017). Assessing the Role of the Ketogenic Diet as a Metabolic Therapy in Cancer: Is it Evidence Based?

21 Stafford et al (2010). The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma

22 Woolf et al (2015). The Ketogenic Diet Alters the Hypoxic Response and Affects Expression of Proteins Associated with Angiogenesis, Invasive Potential and Vascular Permeability in a Mouse Glioma Model

23 Woolf et al (2016). Tumour Metabolism, the Ketogenic Diet and β-Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumour Therapy

24 Rieger et al (2014). ERGO: A pilot study of ketogenic diet in recurrent glioblastoma

25 Martinez-Outschoorn et al (2011). Ketones and lactate increase cancer cell stemness

26 Bonuccelli et al (2010). Ketones and lactate ‘fuel’ tumour growth and metastasis

27 Martinez-Outschoorn et al (2012). Ketone body utilization drives tumour growth and metastasis

28 NICE (2010). Cardiovascular Disease Prevention

29 Hooper (2015). Reduction in Saturated Fat Intake For Cardiovascular Disease

30 PHE (2016). NDNS Results from Years 5 and 6 of the Rolling Programme (2012/2013–2013/2014)


1 Nwaru BI, Hickstein L, Panesar SS, Muraro A, Werfel T, Cardona V, Dubois AE, Halken S, Hoffmann-Sommergruber K, Poulsen LK et al. The epidemiology of food allergy in Europe: a systematic review and meta-analysis. Allergy 2014, 69: 62-75

2 Medicine Io: Food Allergies: Global Burden, Causes, Treatment, Prevention and Public Policy. Edited by. Washington: National Academy of Sciences; 2016. vol 2017

3 Venter C, Mazzocchi A, Maslin K, Agostoni C: Impact of elimination diets on nutrition and growth in children with multiple food allergies. Curr Opin Allergy Clin Immunol 2017, 17: 220-226

4 Venter C, Sommer I, Moonesinghe H, Grundy J, Glasbey G, Patil V, Dean T. Health-related quality of life in children with perceived and diagnosed food hypersensitivity. Pediatr Allergy Immunol 2015, 26: 126-132

5 DunnGalvin A, Dubois AE, Flokstra-de Blok BM, Hourihane JO: The effects of food allergy on quality of life. Chem Immunol Allergy 2015, 101: 235-252.

6 Greenhawt M. Food allergy quality of life. Ann Allergy Asthma Immunol 2014, 113: 506-512

7 Gowland HM. Food labelling. Edited by; 2002

8 Wolf WA, Jerath MR, Sperry SL, Shaheen NJ, Dellon ES. Dietary elimination therapy is an effective option for adults with eosinophilic esophagitis. Clin Gastroenterol Hepatol 2014, 12: 1272-1279

9 Probst YH, Harvey J; O’Sullivan A. Applications of e-health and novel technologies in nutrition research: adapting our research needs to shifts in the landscape. Journal of Human Nutrition and Dietetics 2016, E-Health: http://onlinelibrary.wiley.com/store/10.1111/(ISSN)1365-1277X